Objective  To investigate the prediction function of soluble semaphorin 4D (sSema4D) level in acute ST segment elevation myocardial infarction (STEMI) with high thrombosis load.

  Methods  A total of 46 patients diagnosed with STEMI were selected as STEMI group (20 patients with high thrombotic load and 26 patients without high thrombotic load), and 40 patients with unstable angina (UA) were selected as UA group. Forty patients with negative coronary angiography (CAG) during the same period were selected as control group. The serum sSema4D levels of patients in three groups were determined, and the value of sSema4D in predicting coronary thrombosis load was evaluated; the correlation between serum sSema4D level and high-sensitivity C-reactive protein (hs-CRP) in STEMI patients was analyzed.

  Results  The expression levels of sSema4D in peripheral blood of STEMI patients were significantly higher than that of the control group, and the expression levels of sSema4D in STEMI patients with high thrombotic load were significantly higher than that of STEMI patients without high thrombotic load (P < 0.05). Serum sSema4D was positively correlated with hs-CRP in STEMI patients (P < 0.05), and the correlation coefficient was 0.384.

  Conclusion  The sSema4D expression levels are higher in STEMI patients with high thrombotic load, which may be of certain value in predicting coronary thrombosis.