Objective  To observe the effect of modified protective enterostomy for elderly patients with obstructive sigmoid carcinoma, and analyze the changes of inflammatory factors during perioperation.

  Methods  A total of 96 patients with obstructive sigmoid colon cancer undergoing surgery were selected, and were divided into observation group (n=50) and control group (n=46) according to randomized blinded method. The observation group was treated with improved protective enterostomy, and the control group was treated with loop ileostomy. The therapeutic efficacy, inflammatory factors, serum gastrin (GAS), hepatocyte growth factor (HGF), occurrence of complications and prognosis were compared.

  Results  After surgery of phase Ⅰ and Ⅱ, the postoperative fasting time, hospitalization and exhaust time in the observation group were shorter than the control group (P < 0.05); the total incidence of postoperative complications was lower than that of the control group (P < 0.05). After surgery, the serum levels of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), GAS and HGF in the observation group were lower than those in the control group, and the scores of all dimensions in the 36-item Shot-form Health Status Survey (SF-36) were higher than those in the control group (P < 0.05). The cumulative recurrence rate and cumulative mortality in the observation group 24 months after operation were lower than those in control group (P < 0.05).

  Conclusion  Modified protective enterostomy has a significant effect for elderly patients with obstructive sigmoid carcinoma, which can effectively reduce inflammatory factors, promote postoperative recovery, and improve the quality of life and long-term prognosis of patients.