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光动力治疗宫颈低级别上皮内瘤变的疗效观察

Effect of photodynamic therapy in treatment of low-grade cervical intraepithelial neoplasia

    摘要
  • 摘要:
      目的  观察光动力疗法（PDT）治疗低级别宫颈鳞状上皮内病变（LSIL）的效果及对血清低密度脂蛋白受体相关蛋白-6（LRP-6）、透明质酸（HA）表达的影响。
      方法  研究纳入90例LSIL患者，采用随机数字表法分为2组，每组45例。对照组采用CO2激光治疗，观察组采用PDT治疗，每月治疗1次，治疗3次后观察6个月。比较2组治疗效果、血清LRP-6和HA水平、不良反应及复发情况。
      结果  观察组治疗3个月时整体治疗效果优于对照组，且治疗总有效率高于对照组（P < 0.05）；治疗结束时，2组血清LRP-6、HA水平均较治疗前降低，且观察组低于对照组，差异有统计学意义（P < 0.05）；2组治疗期间不良反应发生率比较，差异无统计学意义（P>0.05）；观察组治疗结束随访6个月时的复发率低于对照组，但差异无统计学意义（P>0.05）。
      结论  LSIL患者采用PDT治疗有较好的临床效果，并可调节患者血清LRP、HA水平。

     

    Abstract:
      Objective  To observe effect of photodynamic therapy (PDT) in treatment of low-grade cervical squamous intraepithelial lesion (LSIL) and its influences on expressions of serum low-density lipoprotein receptor associated protein-6 (LRP-6) and hyaluronic acid (HA).
      Methods  A total of 90 patients with LSIL were prospectively included,and were divided into two groups according to random number table method,with 45 cases in each group.The control group was treated with CO2laser,and the observation group was treated with PDT,the patients were treated once a month and observed for 6 months after 3 times of treatment.The treatment effect,levels of serum LRP-6 and HA,adverse reactions and recurrence of the two groups were compared.
      Results  The overall treatment effect of the observation group at 3 months of treatment was better than that of the control group,and the total effective rate was higher than that of the control group (P < 0.05); at the end of treatment,the levels of serum LRP-6 and HA in both groups were decreased than those before treatment,and were lower in the observation group than those in the control group (P < 0.05).There was no significant difference in the incidence of adverse reactions between two groups during treatment (P>0.05).The recurrence rate of the observation group after 6 months of follow-up was lower than that of the control group(P>0.05).
      Conclusion  PDT has good clinical effect in the treatment of patients with LSIL,can regulate the levels of serum LRP and HA.

     

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