Objective  To investigate the clinical effect of high-frequency chest wall oscillation (HFCWO) combined with bronchoscopy lavage in treatment of ischemic stroke associated pneumonia.

  Methods  Sixty patients with ischemic stroke associated pneumonia were randomly divided into observation group and control group, with 30 cases in each group. On basics of the usual treatment, the control group was treated with bronchoscopy lavage, while the observation group was treated with bronchoscopy lavage combined with HFCWO. The curative effect, blood gas index, inflammatory factors, sputum volume, pulmonary infection score (CPIS) and Barthel index (BI) were compared between the two groups.

  Results  The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). On the 7th, 14th and 21st day of treatment, arterial partial pressure of oxygenp_a(O₂), oxygenation indexp_a(O₂)/FiO₂ and BI scores in observation group were significantly higher than those in the control group, arterial partial pressure of carbon dioxidep_a(CO₂), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), C-reactive protein (CRP) and CPIS scores were significantly lower than those in the control group.

  Conclusion  HFCWO combined with bronchoscopy lavage in the treatment of ischemic stroke associated pneumonia can optimize respiratory tract management, effectively control pulmonary infection and inflammatory response, improve oxygenation index, and enhance clinical efficacy and living ability of patients.