Abstract: Nerve stimulation is a neural control technology that adjusts the central nervous system or peripheral nervous system function of by current stimulation. In recent years, it has been successfully applied in the chronic neural mental illnesses such as epilepsy, Parkinson's disease, refractory depression and obsessive-compulsive disorder, and obtains widely concern due to the advantages of safety, affordable price, good tolerance, and less side effects, etc. With the development of neurostimulation technology, a growing number of animal experiments and clinical researches revealed that neurostimulation might play an anti-inflammatory role in some inflammatory diseases by activating the pathways including cholinergic anti-inflammatory pathway and hypothalamic-pituitary-adrenal, etc. This article reviewed the effects and mechanisms of neurostimulation in anti-inflammatory therapy, in order to provide new methods and ideas for anti-inflammatory treatment.