肺癌患者免疫治疗所致皮肤毒性反应症状研究

A research on symptoms of skin toxicity induced by immunotherapy in patients with lung cancer

  • 摘要:
      目的  探讨多学科症状管理对肺癌患者免疫治疗所致皮肤毒性反应症状的效果。
      方法  选取上海市胸科医院肿瘤内科病房收治的115例肺癌免疫治疗患者,实施药物及非药物治疗相结合的症状管理措施。药物干预包括抗过敏及类固醇激素类用药;非药物干预包括放松疗法及润肤剂应用等。
      结果  实施症状管理后,免疫治疗所致的皮疹及瘙痒症状较干预前降低,且多数患者皮疹及瘙痒程度为1~2级;除社会与家庭状况外,患者的生理状况、情感状况、功能状况及附加关注度优于症状管理前,差异具有统计学意义(P < 0.05)。
      结论  规范化皮肤毒性管理能改善肺癌患者的症状体验,提高患者的生活质量。

     

    Abstract:
      Objective  To explore the effect of multidisciplinary symptom management on symptoms of skin toxicity caused by immunotherapy in patients with lung cancer.
      Methods  A total of 115 lung cancer patients with immunotherapy in Department of Oncology in Shanghai Chest Hospital were selected and treated with symptom management measures of drug and non-drug treatments in combination. Drug interventions included anti-allergy and steroid drugs, while non-drug interventions included relaxation therapy and application of emollients.
      Results  After the implementation of symptom management, the rash and pruritus symptoms caused by immunotherapy alleviated compared with before intervention (P < 0.05), and the rash and pruritus degree in most patients was grade 1 to 2. Except for social and family status, the physiological status, emotional status, functional status and additional attention of patients were significantly better than those before symptom management (P < 0.05).
      Conclusion  Standardized skin toxicity management can improve the symptom experience of lung cancer patients and improve the qualities of life of patients.

     

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