Objective  To investigate the effect of whole-course intestinal microecological intervention intestinal microecological intervention on complications after operation and during chemotherapy in patients with colon cancer.

  Methods  Seventy-nine patients with colon cancer were selected as study objects and were divided into intervention group (n=40) and control group (n=39) according to whether patients were treated with Bifidobacterium Triple Viable Bacteria Tablets. The control group received conventional radical resection of colon cancer and chemotherapy, and the intervention group received Bifidobacterium Triple Viable Bacteria Tablets from 5 days before surgery until the end of chemotherapy. Postoperative recovery of gastrointestinal function and occurrence of complications in both groups were recorded. Serum inflammatory response indexes were compared after operation and during chemotherapy.

  Results  The postoperative recovery time of anal exhaust and defecation time in the intervention group were significantly shorter compared with the control group (P < 0.05). The overall incidence of postoperative complications and the incidence of various types of complications during chemotherapy in the intervention group were lower than those in the control group (P < 0.05). Serum inflammatory indexes in the intervention group after surgery and during chemotherapy were significantly lower than those in the control group (P < 0.05).

  Conclusion  The administration of Bifidobacterium Triple Viable Bacteria Tablets for colon cancer patients during period of perioperation and chemotherapy can significantly shorten the time of postoperative gastrointestinal function recovery, and at the same time, it is beneficial to suppress inflammation, reduce the incidence of complications after radical resection of colon cancer and during chemotherapy, and help to promote the outcome of the disease.