Objective   To explore the diagnostic values of full-field digital mammography (FFDM) alone, digital breast tomography (DBT) alone and their combination in the diagnosis of benign or malignant breast lesions and breast calcification.

  Methods   A total of 280 patients with suspected breast lesions were selected as research objects, and all patients received FFDM and DBT examinations. The diagnostic accuracy of FFDM or DBT alone and their combination in the diagnosis of benign or malignant breast lesions and breast calcification was compared. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of FFDM, DBT and FFDM combined with DBT for breast lesions.

  Results   The positive prediction value of FFDM was 63.53% and the negative prediction value was 85.21%; the positive prediction value of DBT was 78.75% and the negative prediction value was 90.80%; the positive prediction value of DBT combined with FFDM was 92.50%, and the negative prediction value was 97.13%. The accuracy rates of FFDM combined with DBT in diagnosis of benign, malignant breast lesions and breast calcification were higher than that of DBT and FFDM alone, and the accuracy rates of DBT in diagnosis of benign and malignant breast lesions and breast calcification were higher than those of FFDM (P < 0.05). ROC curve analysis showed that the area under curve (AUC) of FFDM, DBT and FFDM combined with DBT in early prediction of breast lesions were 0.753, 0.850 and 0.951, respectively.

  Conclusion   DBT combined with FFDM have higher diagnostic value for breast lesions, effectively distinguish benign and malignant lesions, and increase the detection rate of breast calcification.