Abstract:
Objective To investigate the clinical characteristics of Helicobacter pylori (Hp) infected patients with low delta over baseline (DOB) values and observe the efficacy of TCM therapy.
Methods Clinical data of 144 cases who was diagnosed with positive results by 13C-urea breath testdelta over baseline (DOB) value ranging from>4.0 to < 16.0 were collected. The above patients were divided into quadruple therapy group (72 cases, proton pump inhibitor, bismuth and two antibiotics) and TCM group (72 cases, Chinese herbal medicine or Chinese patent medicine). The treatment duration was 2 weeks for quadruple therapy group, and 4 weeks for TCM group, and all cases were reexamined. TCM syndrome differentiation characteristics of Hp infected patients with low DOB values and the law of TCM therapy were observed; the clinical effects and adverse reactions were compared between the two groups.
Results TCM syndromes of Hp infected patients with low DOB values were mainly syndrome of dampness and heat of spleen and stomach; as for the usage frequency of Chinese patent medicine, the top three were JingHua Weikang Capsule, MoLuo Dan, Weifu Chun; as for the usage frequency of Chinese herb medicine, the top three were Pugongying, Huanglian, and Huangqin. The TCM group had better results for clinical symptoms improvement and incidence of adverse reactions than that of the quadruple therapy group (P < 0.05). There was no statistical difference in eradication rate between the quadruple therapy group and the TCM group (P>0.05).
Conclusion Hp infected patients with low DOB values are featured with syndrome of dampness and heat in the spleen and stomach. The therapy of TCM syndrome differentiation has better curative effects on Hp infected patients, and has significant advantages in improving clinical symptoms and reducing adverse reactions.
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