动物源抗菌肽治疗鲍曼不动杆菌感染的研究进展

Research progress on animal-derived antimicrobial peptides for treatment of Acinetobacter baumannii infection

摘要: 鲍曼不动杆菌是一种革兰阴性菌，是重要的病原菌之一。由于抗生素的滥用，多重耐药鲍曼不动杆菌的检出率越来越高。抗菌肽作为细菌感染治疗的替代品，是从生物体中自然产生的，具有快速杀伤和高效广谱的抗菌活性。本文对人源、两栖动物源、昆虫源抗菌肽在治疗鲍曼不动杆菌感染中的作用、机制和应用前景进行综述。

Abstract: Acinetobacter baumannii, a Gram-negative bacterium, is one of the most important pathogens. Due to the abuse of antibiotics, the detection rate of multi-drug resistant Acinetobacter baumannii is increasing. Antimicrobial peptides have been considered as alternatives to the treatment of bacterial infections, which are naturally produced from organisms, and have rapid killing and high-efficiency broad-spectrum antimicrobial activities. This paper reviewed the function, mechanism and application prospect of several kinds of antimicrobial peptides in the treatment of Acinetobacter baumannii.