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循环肿瘤细胞、微小核糖核酸-1246、糖类抗原153在乳腺癌中的表达及其与临床病理特征和预后的关系

Expressions of circulating tumor cells, microribonucleic acid 1246, carbohydrate antigen 153 in breast cancer patients and their relationships with different clinicopathological features and prognosis

    摘要
  • 摘要:
      目的   观察循环肿瘤细胞(CTCs)、微小核糖核酸-1246(miR-1246)、糖类抗原153(CA153)乳腺癌中的表达情况，并分析其与乳腺癌患者不同临床病理特征和预后的关系。
      方法   采用回顾性方法选取108例乳腺癌患者纳入乳腺癌组，选取乳腺良性肿瘤患者100例纳入良性肿瘤组，另选取同期体检中心的100例健康体检者纳入对照组。比较3组CTCs、miR-1246、CA153的表达差异，并分析CTCs、miR-1246、CA153的诊断价值及与乳腺癌患者临床病理特征和预后的关系。
      结果   乳腺癌组CTCs、miR-1246、CA153水平高于良性肿瘤组，良性肿瘤组CTCs、miR-1246、CA153水平高于对照组，差异有统计学意义(P < 0.05)。CTCs、miR-1246、CA153三者联合检测的诊断效能高于单独检测，灵敏度、特异度可分别达到90.1%、84.8%。CTCs、miR-1246、CA153水平与乳腺癌患者的年龄、病理类型、TNM分期、组织学分级、淋巴结转移密切相关(P < 0.05)。TNM分期、组织学分级、淋巴结转移情况和CTCs、miR-1246、CA153表达情况均是乳腺癌患者预后的独立影响因素(P < 0.05)。
      结论   CTCs、miR-1246、CA153表达水平在乳腺癌患者中明显升高，且与乳腺癌患者不同临床病理特征及预后密切相关，三者联合检测可作为早期诊断及预后判断的有效指标。

     

    Abstract:
      Objective   To observe the expressions of circulating tumor cells (CTCs), microribonucleic acid 1246 (MiR-1246), carbohydrate antigen 153 (CA153) levels in breast cancer patients, and to explore their relationships with different clinicopathological features and prognosis.
      Methods   A total of 108 patients with breast cancer were enrolled as breast cancer group, and another 100 patients with benign breast tumor were enrolled as benign tumor group. During the same period, 100 healthy subjects with physical examinations were collected as control group. The expression differences of CTCs, miR-1246 and CA153 among the three groups were compared, their diagnostic values and their relationships with the clinicopathological characteristics and prognosis of breast cancer patients were analyzed.
      Results   The levels of CTCs, miR-1246 and CA153 in the breast cancer group were significantly higher than those in the benign tumor group, and the above indicators in the benign tumor group were significantly higher than those in the control group (P < 0.05). The diagnostic efficiency of the combined detection was significantly higher than the detection alone, and the sensitivity and specificity reached 90.1% and 84.8%. The levels of CTCs, miR-1246 and CA153 were closely correlated with age, pathological type, TNM stage, histological grade and lymph node metastasis of breast cancer patients (P < 0.05). TNM stage, histological grade, lymph node metastasis, CTCs, miR-1246, and CA153 expressions were independent risk factors for prognosis of breast cancer patients.
      Conclusion   CTCs, miR-1246 and CA153 expressions are significantly increased in breast cancer patients, and are closely related to different clinicopathological characteristics and prognosis of breast cancer patients. Combined detection can be used as effective indicators for early diagnosis for breast cancer and judgment of prognosis.

     

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