轻度胃肠炎伴婴幼儿良性惊厥患儿细胞炎症因子、免疫水平及脑脊液中髓鞘碱性蛋白、神经元特异性烯醇化酶水平变化与临床意义

王红芳; 李树华; 张润春; 张彦博

doi:10.7619/jcmp.20211644

轻度胃肠炎伴婴幼儿良性惊厥患儿细胞炎症因子、免疫水平及脑脊液中髓鞘碱性蛋白、神经元特异性烯醇化酶水平变化与临床意义

Changes of cellular inflammatory factors, immune levels, myelin basic protein and neuron-specific enolase levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis and their clinical significance

摘要

摘要:
目的探讨轻度胃肠炎伴婴幼儿良性惊厥（BICE）患儿细胞炎症因子、免疫水平及脑脊液中髓鞘碱性蛋白（MBP）、神经元特异性烯醇化酶（NSE）水平的变化与临床意义。
方法选取42例BICE患儿为观察组，并将观察组患儿按照发生惊厥次数分为A、B组，A组18例患儿为惊厥发生 < 2次，B组24例为惊厥发生≥2次，同期选取42例轻度胃肠炎但不伴有惊厥发作患儿为对照组。观察各组患儿细胞炎症因子、免疫水平及脑脊液中MBP、NSE水平。
结果观察组患儿肿瘤坏死因子-α（TNF-α）、干扰素-γ（INF-γ）、白细胞介素-6（IL-6）水平高于对照组，CD3⁺、CD4⁺及CD4⁺/CD8⁺水平低于对照组，差异有统计学意义（P < 0.05）。观察B组患儿TNF-α、IL-6、INF-γ水平高于观察A组，CD3⁺、CD4⁺及CD4⁺/CD8⁺水平低于观察A组，差异有统计学意义（P < 0.05）；观察B组患儿脑脊液S-100β蛋白（S-100β）、NSE水平高于观察A组，差异有统计学意义（P < 0.05）。
结论在BICE患儿发生惊厥过程中，观察其细胞炎症因子、免疫水平及脑脊液中MBP、NSE水平的变化具有重要临床价值，可了解患儿的身体状况，有利于筛查高风险患儿和制定相关防治措施。

Abstract:
Objective To investigate the changes of cellular inflammatory cytokines, immune levels, myelin basic protein (MBP) and neuron-specific enolase (NSE) levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis (BICE) and their clinical significance.
Methods Forty-two children with BICE were selected as the observation group, and the children in the observation group were divided into group A and group B according to the frequency of convulsion. A total of 18 cases in group A had convulsion less than 2 times, 24 cases in group B had convulsion 2 times and above, and 42 children with mild gastroenteritis without convulsion were selected as the control group. Cellular inflammatory cytokines, immune levels, MBP and NSE levels in cerebrospinal fluid were observed in each group.
Results The levels of tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ) and interleukin-6 (IL-6) in the observation group were significantly higher than those in control group, and the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the observation group were significantly lower than those in the control group (P < 0.05). The levels of TNF-α, IL-6 and INF-γ in the group B were significantly higher than those in the group A, and the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the group B were significantly lower than those in the group A (P < 0.05). The levels of S-100β protein (S-100β) and NSE in cerebrospinal fluid in the group B were significantly higher than those in the group A (P < 0.05).
Conclusion In the process of seizures in children with BICE, it is of great clinical value to observe the changes of cellular inflammatory cytokines, immune levels and the levels of MBP and NSE in cerebrospinal fluid, so as to understand the physical conditions of the children and facilitate the screening of high-risk children and the formulation of related prevention and treatment measures.

HTML全文

参考文献(24)

施引文献

资源附件(0)