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蒲黄炭联合寿胎丸对肾虚型先兆流产合并绒毛膜下血肿患者的影响

Effects of Puhuang Charcoal combined with Shoutai Pills for subchorionic hematoma patients with threatened abortion due to deficiency of kidney

    摘要
  • 摘要:
      目的  探讨蒲黄炭联合寿胎丸对肾虚型先兆流产合并绒毛膜下血肿患者临床疗效、证候评分及妊娠结局的影响。
      方法  回顾性分析86例肾虚型先兆流产合并绒毛膜下血肿患者的临床资料，根据患者接受治疗方式的不同将其分为2组，对照组46例采用黄体酮胶囊治疗，观察组40例在对照组基础上加以蒲黄炭联合寿胎丸治疗。比较2组临床疗效、中医证候评分、B超血肿消失时间、阴道出血时间、妊娠结局、性激素水平及不良反应发生情况。
      结果  观察组总有效率为90.00%，高于对照组的71.74%，差异有统计学意义（P < 0.05）。治疗后，2组中医证候主证积分与次证积分均下降，且观察组低于对照组，差异有统计学意义（P < 0.05）。观察组B超血肿消失时间及阴道出血时间较对照组更短，差异有统计学意义（P < 0.05）。2组难免流产率比较，差异无统计学意义（P>0.05）。治疗后，2组人绒毛膜促性腺激素（HCG）、孕酮（P）、雌二醇（E2）水平升高，且观察组以上指标水平高于对照组，差异有统计学意义（P < 0.05）。对照组治疗期间共出现不良反应3例（6.52%），观察组4例（10.00%），2组不良反应发生率比较，差异无统计学意义（P>0.05）。
      结论  蒲黄炭联合寿胎丸可有效提高肾虚型先兆流产合并绒毛膜下血肿患者疗效，降低中医证候评分，提高孕激素水平。

     

    Abstract:
      Objective  To investigate effect of Puhuang Charcoal combined with Shoutai Pills on the clinical efficacy, syndrome score and pregnancy outcomes of subchorionic hematoma patients with threatened abortion due to deficiency of kidney.
      Methods  The clinical data of 86 subchorionic hematoma patients with threatened abortion due to deficiency of kidney was retrospectively analyzed. The patients were divided into two groups according to different treatment methods. The control group(46 cases) was treated with progesterone capsules, and the observation group (40 cases) were treated with Puhuang Charcoal combined with Shoutai Pills on the basis of the control group. The clinical efficacy, TCM syndrome score, B-ultrasonic hematoma disappearance time, vaginal bleeding time, pregnancy outcomes, sex hormone levels and adverse reactions were compared between the two groups.
      Results  The total effective rate of the observation group was 90.00%, which was higher than 71.74% of the control group (P < 0.05). After treatment, the scores of the main syndromes and secondary syndromes of the two groups decreased significantly, but were lower in the observation group than those in the control group(P < 0.05). The disappearance time of B-ultrasound hematoma andvaginal bleeding in the observation group were shorter than those in the control group (P < 0.05). There was no statistically significant difference in the inevitable abortion rate between the two groups (P>0.05). After treatment, the levels of human chorionic gonadotropin (HCG), progesterone (P) and estradiol (E2) in the two groups were increased, and the levels of above indexes in the observation group were higher than those in the control group (P < 0.05). There were 3 cases (6.52%) of adverse reactions in the control group and 4 cases (10.00%) in the observation group during the treatment, but there was no statistically significant difference between the two groups (P>0.05).
      Conclusion  The combined treatment of Puhuang Charcoal and Shoutai Pills can effectively improve curative effect of threatened abortion patients with kidney-deficiency, reduce the syndrome score of TCM, and increase the level of progesterone.

     

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