Abstract: Invasive stratified mucin-producing carcinoma (ISMC) is a rare type of human papillomavirus (HPV) associated cervical adenocarcinoma. ISMC had been included into the fifth edition of the World Health Organization (WHO) classification of female genital tumors, and it is of great significance to understand and master the clinical and pathological characteristics of this kind of lesions. In this article, we revieed the related literatures on clinical features, histopathology, immunophenotypes and special dyeing, ISMC associated lesions in situ, differential diagnosis, treatment and prognosis, hoping to deepen the understanding of this disease in clinicians and pathologists.