Objective  To explore the effects of pranoprofen combined with sodium hyaluronate on visual function, tear inflammatory factors and vision-related quality of life (VRQOL) in adolescent patients with dry eye disease (DED).

  Methods  A total of 100 DED patients were selected as research objects and divided into observation group (pralprofen combined with sodium hyaluronate, 50 cases) and control group (sodium hyaluronate alone, 50 cases) according to random number table method. Clinical efficacy, adverse reactions, visual function, tear inflammatory factor level and VRQOL score before and after treatment were compared between the two groups.

  Results  The total effective rate of the observation group was 90.00%, which was significantly higher than 74.00% of the control group (P < 0.05). After treatment, the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), interleukin-1 β (IL-1β) and tumor necrosis factor -α (TNF-α) in tears in the observation group were significantly lower than those in the control group, and VRQOL score was significantly higher than that in the control group (P < 0.05). There was no significant difference in subjective symptom score between the two groups (P>0.05).

  Conclusion  Pralprofen combined with sodium hyaluronate has significant efficacy in treatment of adolescents with DED, which can improve the visual function of adolescent patients, reduce the inflammatory response of tears, and improve the vision-related quality of life.