Eph/Ephrin信号通路在原发性骨肿瘤及骨癌疼痛中的作用研究进展

Research progress on roles of Eph/Ephrin signaling pathway in primary bone tumor and bone cancer pain

摘要: 促红细胞生成素肝细胞激酶（Eph）受体及其配体Ephrin在神经系统的轴突引导、神经祖细胞的迁移和血管生成等过程中扮演重要角色。Eph和Ephrin的异常表达与许多肿瘤的发生、发展、转移、预后以及耐药性等关系密切，参与了机体的许多生理和病理过程，但目前的研究还很有限。本研究主要对Eph和Ephrin在原发性骨肿瘤及转移性骨肿瘤导致的骨癌疼痛（BCP）中的作用进行综述。

Abstract: Erythropoietin producing hepatocyte kinase (Eph) receptor and its ligand Ephrin play important roles in axon guidance, migration of neural progenitor cells and angiogenesis. The abnormal expressions of Eph and Ephrin are closely related to the occurrence, development, metastasis, prognosis and drug resistance of many tumors, and involve in many physiological and pathological processes, but the current research is still limited.This study mainly reviewed the roles of Eph and Ephrin in bone cancer pain (BCP) caused by primary and metastatic bone tumors.