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盐酸川芎嗪眼部雾化联合耳尖放血对气阴两虚型糖尿病视网膜病变的疗效观察

Clinical effect of ligustrazine hydrochloride eye nebulization combined with ear tip bloodletting in the treatment of diabetic retinopathy differentiated as qi and yin deficiency

    摘要
  • 摘要:
      目的  观察盐酸川芎嗪眼部雾化联合耳尖放血对气阴两虚型糖尿病视网膜病变的临床疗效。
      方法  选取80例糖尿病视网膜病变患者随机分为对照组和观察组，每组40例。对照组采用常规降糖措施和改善循环治疗措施，观察组在对照组基础上加用盐酸川芎嗪注射液眼部雾化联合耳尖放血疗法。比较2组治疗前后视功能情况（眼睛干涩评分、视物模糊程度评分和视力）、血糖相关指标空腹血糖（FPG）、餐后2 h血糖（2 hPG）和糖化血红蛋白（HbAlc）、眼底情况（黄斑中心视网膜厚度）、中医证候积分改善情况和疗效。
      结果  治疗后，2组视功能、眼底情况均优于治疗前，且观察组优于对照组，差异有统计学意义（P < 0.05）。治疗后，2组FPG、2 hPG、HbAlc水平均低于治疗前，差异有统计学意义（P < 0.05）；治疗后，2组FPG、2 hPG、HbAlc水平比较，差异无统计学意义（P>0.05）。治疗后，2组中医证候积分均低于治疗后，且观察组低于对照组，差异有统计学意义（P < 0.05）；治疗3个月后，观察组总有效率高于对照组，差异有统计学意义（P < 0.05）。
      结论  盐酸川芎嗪眼部雾化联合耳尖放血可改善气阴两虚型糖尿病视网膜病变患者的眼部症状，调节血糖相关指标水平，延缓视网膜并发症进程。

     

    Abstract:
      Objective  To observe the clinical efficacy of ligustrazine hydrochloride eye nebulization combined with ear tip bloodletting in the treatment of diabetic retinopathy differentiated as qi and yin deficiency.
      Methods  A total of 80 patients with diabetic retinopathy were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with conventional hypoglycemic and improved circulation treatment. In the observation group, ligustrazine hydrochloride injection eye nebulization combined with ear tip bloodletting was added on the basis of the control group. Visual conditions (dry eyes score, blurred vision score, and eyesight), blood glucose related indicatorsfasting blood glucose (FPG), postprandial blood glucose at 2 h (2 hPG) and glycosylated hemoglobin(HbAlc), and fundus conditions (macular central retinal thickness), clinical efficacy and the improvement of TCM syndrome score were compared between the two groups.
      Results  The visual function and fundus condition of the two groups were improved after treatment, and the observation group was significantly better than the control group (P < 0.05); after treatment, FPG, 2 hPG, HbAlc of the two groups were significantly lower than those before treatment (P < 0.05), but the blood glucose indexes of the observation group showed no statistically significant difference compared with the control group (P>0.05). TCM syndrome score of the two groups was significantly lower after treatment, and the observation group was significantly lower than that of the control group (P < 0.05). After 3 months of treatment, the total effective rate of observation group was significantly higher than that of the control group (P < 0.05).
      Conclusion  Ligustrazine hydrochloride eye nebulization combined with ear tip bloodletting can improve the symptoms of ocular in patients with diabetic retinopathy of deficiency of both qi and yin, regulate blood glucose-related indicators, and delay the progression of retinal complications.

     

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