Objective  To explore the value of 3.0T magnetic resonance imaging plus susceptibility weighted imaging (MRI-SWI) in evaluating basal ganglia volume in patients with Parkinson's disease (PD) at different stages.

  Methods  The materials of 96 PD patients were retrospectively analyzed, and all of them were conducted with 3.0T MRI-SWI examination. According to Hoehn Yahr (H-Y) classification standard, the PD patients were divided into early stage group (n=37), middle stage group (n=46) and advanced stage group (n=13). The volumes of region of interest in left and right basal ganglia of PD patients with different stages were compared, and the correlation between the total volume of region of interest in basal ganglia and stages was analyzed.

  Results  In PD patients with different stages, the volumes of left and right globus pallidus, putamen and caudate nucleus were the smallest in the advanced stage group and the largest in the early stage group, and there were significant differences among three groups (P < 0.05). Kendall's tau-b correlation analysis showed that the staging was significantly negatively correlated with the total volume of region of interest of the basal ganglia in PD patients (P < 0.05).

  Conclusion  3.0T MRI-SWI has a high value in evaluating basal ganglia volume of PD patients with different stages, and there is a significant negative correlation between basal ganglia volume and stages.