Abstract: Zinc finger proteins are the largest family of transcription factors in the human genome. Various combinations of zinc finger structures determine different functions in biological behavior, including regulation of gene expression, cell differentiation and embryonic development at the level of transcription and translation. The mechanism of action of different zinc finger proteins in the malignant process of cancer needs to be further studied. In this article, the mechanism of C2H2 zinc finger protein transcription regulation and post-translational modification was briefly reviewed, and its regulatory roles in different tumors were summarized.