Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer
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摘要:目的 观察硒酵母片联合同步放化疗治疗ⅡB期宫颈癌患者的近期疗效。方法 纳入宫颈癌患者103例，将其随机分为对照组53例和实验组50例。实验组给予口服硒酵母片，对照组给予安慰剂，2组均给予含顺铂的同步放化疗方案。放疗结束后，通过实验室指标及影像学检查结果评估治疗前后病灶大小，骨髓抑制和肝、肾功能损伤程度。结果 2组总有效率比较，差异有统计学意义（P < 0.05）。实验组与对照组骨髓抑制、肾损伤、肝损伤等毒副作用发生率比较，差异均无统计学意义（P>0.05）。结论 中晚期宫颈癌患者同步放化疗过程中服用硒酵母片的近期疗效优于单纯放化疗。Abstract:Objective To observe the short-term efficacy of selenium yeast combined with concurrent chemoradiotherapy for patients with stage ⅡB cervical cancer.Methods One hundred and three cervical cancer patients were included and randomly divided into experimental group (n=50) and control group (n=53). The experimental group was given oral selenium yeast, while control group was given placebo, and both groups received concurrent chemoradiotherapy with cisplatin. After radiotherapy, the tumor lesion, myelosuppression, liver and kidney impairment were assessed by laboratory indicators and imaging results.Results There were statistically significant difference in total effective rate between the two groups (P < 0.05). There was no significant difference in the incidence of bone marrow suppression, kidney injury, liver injury and other toxic and side effects between the experimental group and the control group (P>0.05).Conclusion The short-term efficacy of selenium yeast tablets during concurrent chemoradiotherapy in patients with advanced cervical cancer is better than that of chemoradiotherapy alone.
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表 1 2组毒性反应分级比较[n(%)]
毒性反应 实验组(n=50) 对照组(n=53) Ⅰ度 Ⅱ度 Ⅲ度 Ⅳ度 Ⅰ度 Ⅱ度 Ⅲ度 Ⅳ度 骨髓抑制 8(16.00) 25(50.00) 15(30.00) 2(3.77) 8(15.09) 21(39.62) 18(33.96) 4(7.55) 肝功能异常 30(60.00) 7(14.00) 0 0 23(43.40) 4(7.55) 1(1.89) 1(1.89) 肾功能异常 9(18.00) 0 0 0 5(9.43) 2(3.77) 0 0 
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