Objective  To investigate the related factors of patients' quality of life after catheter-directed thrombolysis with deep venous thrombosis catheter in different periods.

  Methods  A total of 80 deep vein thrombosis of the lower extremity (DVT) after catheter contact thrombolysis were selected for cross-sectional survey. Patients' general information questionnaire, 36-item Short-form Health Survey (SF-36), General Comfort Questionnaire (GCQ), Social Support Scale, post-thrombotic syndrome(PTS) were used to analyze the general information, life quality, comfort degree, social support conditions, and severity of PTS. One-way ANOVA and multivariate stepwise linear regression were used to analyze the quality of life.

  Results  The scores of quality of life in patients with lower extremity DVT after catheter directed thrombolysis showed a gradual upward trend at discharge, 1 month and 3 months after discharge(P < 0.05). Multiple stepwise linear regression analysis showed that thrombolytic days, urokinase dosage and GCQ score after extubation were the influencing factors of quality of life of patients at discharge after DVT catheter contact thrombolysis; thrombolytic days and urokinase dosage were influencing factors of quality of life at 1 month after DVT catheter contact thrombolysis, and PTS score was the influencing factor of quality of life at 3 months after DVT catheter contact thrombolysis.

  Conclusion  The quality of life of patients with DVT after contact thrombolytic therapy in lower extremities is different in varied periods. Medical staff should pay attention to the related factors that affect their quality of life.