Abstract: China is a high incidence area of primary liver cancer. Most of the patients with liver cancer are in advanced stage at first diagnosis, which has the characteristics of poor treatment effect, poor prognosis and low 5-year survival rate. The pathogenesis of liver cancer is complex, and new targets for the prevention and treatment of liver cancer need to be explored. Neutrophils play a defense role in innate immunity. Studies have found that neutrophils also play an important role in the tumor microenvironment of liver cancer, which participate in the occurrence, development and metastasis of liver cancer. In this study, we analyzed the research progress of tumor-associated neutrophils in the tumor microenvironment of liver cancer, explored the potential therapeutic targets of liver cancer, and provided new ideas for the prevention and treatment of liver cancer.