Abstract: Mannose is a protein glycosylated monosaccharide with molecular formula C₆H₁₂O₆, and it can interfere with glucose metabolism, inhibit fat deposition, regulate intestinal flora and participate in immune regulation. Comprehensive understanding of the mechanism of mannose in the treatment of related diseases is the key to expand its clinical application. In this study, we reviewed the research progress of mannose in anti-tumor, urinary tract infection, obesity, diabetes and other aspects in recent years, explored its mechanism and application prospect, hoping to provide theoretical supports for expanding the clinical application of mannose.