Objective  To observe the effect of catheter directed thrombolysis (CDT) combined with iliofemoral vein stent implantation in treatment of Cockett syndrome complicated with acute deep venous thrombosis (DVT) of lower extremity.

  Methods  The data of 93 patients with Cockett syndrome complicated with acute DVT was retrospectively analyzed and collected. According to the operative methods, they were divided into CDT group (47 cases, treated with CDT) and combined group (46 cases, treated with CDT combined with iliofemoral vein stent implantation). The thrombus clearance rate, the incidence of postoperative complications and recurrence of the two groups were compared. The inflammatory factorsinterleukin-6 (IL-6), C-reactive protein (CRP) in the two groups before and 1 month after operation were compared.

  Results  The grading of clearance rate of thrombus in the combined group was better than that in the CDT group, and the recurrence rate in the combined group was lower than that in the CDT group (P < 0.05). There were no significant differences in the levels of IL-6 and CRP in CDT group before and after operation (P>0.05). The levels of IL-6 and CRP in the combined group at 1 month after operation were higher than those before operation and the CTD group (P < 0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05).

  Conclusion  CDT combined with iliofemoral vein stent implantation in the treatment of patients with Cockett syndrome complicated with acute DVT is helpful to remove thrombus, reduce the recurrence rate, and has higher safety. However, the combined treatment may mediate inflammatory reaction and increase the risk of new thrombosis. Therefore, reasonable anti-inflammatory treatment should be carried out actively after operation.