Objective  To investigate the relationship between Helicobacter pylori (Hp) infection and clinicopathological parameters in elderly patients with colorectal adenoma.

  Methods  A total of 204 elderly patients with colorectal adenoma were included in the colorectal adenoma group and 110 were selected in the control group. Clinical data of the two groups was retrospectively analyzed. The relationships between Hp infection and clinicopathological parameters of colorectal adenoma were observed and analyzed.

  Results  The positive rate of Hp infection in colorectal adenoma group was 54.9%, which was significantly higher than 42.7% in the control group (P < 0.05). In the colorectal adenoma group, the Hp positive infection rate of patients with body mass index (BMI) ≥ 25 kg/m² was significantly higher than that of patients with BMI < 25 kg/m², the positive Hp infection rate of patients with diabetes history was significantly higher than that of those without, and the Hp positive infection rate of patients with smoking history was significantly higher than that of those without (P < 0.05). Hp positive infection rate in patients with proximal adenoma was significantly lower than that in those with distal adenoma, and Hp positive infection rate in patients with low-grade intraepithelial neoplasia was significantly lower than that in those with high-grade intraepithelial neoplasia (P < 0.05).

  Conclusion  Hp infection in elderly colorectal adenoma patients may be correlated with BMI, history of diabetes mellitus, smoking history, location of adenoma and degree of intraepithelial neoplasia.