不同Luminal型乳腺癌超声造影特征分析

巩海燕; 王慧; 邓晶; 查海玲; 周文斌; 栗翠英

doi:10.7619/jcmp.20210737

不同Luminal型乳腺癌超声造影特征分析

Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types

摘要

摘要:
目的探讨不同Luminal型乳腺癌超声造影的特征。
方法对98例Luminal型乳腺癌患者进行术前超声造影检查，分析造影特征与分子分型之间的关系。
结果 Luminal A型与Luminal B型灌注缺损比较，差异有统计学意义（P=0.043）。与Luminal A型比较，Luminal B型灌注缺损较为常见。Luminal A型和Luminal B型有以下相似特征：高增强，整体性增强，造影剂分布不均匀，向心性，边界清晰，形态不规则，无穿入或扭曲血管，无灌注缺损，病灶无显著增大，慢出。Luminal A型与Luminal B型峰值强度（Peak）、曲线下面积（AUC）、Peak差值比较，差异有统计学意义（P < 0.05）。Luminal B型乳腺癌的Peak、Peak差值、AUC高于Luminal A型。
结论不同Luminal型乳腺癌超声造影定性特征及定量参数间存在一定差异，可为术前预测乳腺癌分子分型提供一定影像学信息。

Abstract:
Objective To explore the features of contrast-enhanced ultrasound of breast cancer for different Luminal types.
Methods A total of 98 patients with Luminal breast cancer were examined by preoperative contrast-enhanced ultrasound. The relationships between the characteristics of imaging and molecular subtypes were analyzed.
Results Luminal A type and Luminal B type had statistical significance in perfusion defect (P=0.043). Compared with Luminal A type, it was found that perfusion defect was more frequently seen in Luminal B type. They showed the following similar characteristics: high enhancement, overall enhancement, non-uniform distribution of contrast agent, centrality, clear boundary, irregular shape, no penetration or distortion of blood vessels, no perfusion defect, no expansion of scope, slow backward. There were significant differences in Peak intensity (Peak), Area Under Curve (AUC) and Peak difference between Luminal A type and Luminal B type (P < 0.05). The Peak, Peak difference and AUC of Luminal B type were significantly higher than Luminal A type.
Conclusion There are differences in the characteristics and quantitative parameters between Luminal A type and Luminal B type, which can be used to provide imaging information for preoperative prediction of breast cancer for molecular subtypes.

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