代谢相关性多囊卵巢综合征及其理论基础

Metabolic associated polycystic ovarian syndrome and its theoretical basis

  • 摘要: 多囊卵巢综合征(PCOS)是导致女性不孕的常见因素。肥胖等代谢相关性疾病与PCOS有着密切的联系。基于临床实践和基因组学的研究结果,伴有代谢综合征的PCOS可以认为是代谢综合征在女性生殖系统的特殊表现,可将其作为PCOS的主要亚型单独命名,即代谢相关性多囊卵巢综合征(metabolic associated polycystic ovary syndrome, MAPs)。作者首次创新性提出MAPs的概念,这将有利于改变目前以抗雄激素为主要策略的临床研究和临床实践思路,更加强调针对病因进行治疗,从肠道菌群调节和生活方式干预等方面进行协同干预,为PCOS的精准治疗开辟新的思路。

     

    Abstract: Polycystic ovary syndrome (PCOS) is a common cause of female infertility. Obesity and other metabolic diseases are closely related to PCOS. Based on clinical practice and genomics research results, PCOS combined with metabolic syndrome, a main subtype of PCOS, can be considered as a special manifestation of metabolic syndrome in female reproductive system, so it can be named as metabolic associated polycystic ovary syndrome (MAPs). The author firstly puts forward the concept of MAPS in innovation, which is conducive to change the current clinical practice and clinical research thinking that antiandrogen is considered as the main strategy, pays more emphasis on etiological treatment, and provides coordinated interventions on intestinal flora regulation as well as lifestyle intervention and so on. The concept of MAPS provides a new idea for the precise treatment of PCOS.

     

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