三阴性乳腺癌中间质-上皮细胞转化因子及脂肪酸合成酶的表达情况及对预后的影响

蒋威华; 伊丽娜; 张晨光; 雪来提·派祖拉; 许文婷; 欧江华

doi:10.7619/jcmp.20210355

三阴性乳腺癌中间质-上皮细胞转化因子及脂肪酸合成酶的表达情况及对预后的影响

Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis

摘要

摘要:
目的观察间质-上皮细胞转化因子（c-Met）及脂肪酸合成酶（FASN）在三阴性乳腺癌患者中的表达情况及对预后的影响。
方法采用免疫组织化学染色法（SP）检测218例三阴性乳腺癌组织及癌旁组织中c-Met及FASN蛋白的表达水平，观察c-Met及FASN阳性表达情况，并探讨其与临床病理特征的关系及对预后的影响。
结果 218例患者中c-Met阳性表达130例（59.6%），FASN阳性表达142例（65.1%），高于癌旁组织，且c-Met及FASN阳性表达与患者腋窝淋巴结转移情况、TNM分期和组织学分级相关（P < 0.05），但与肿瘤直径无关（P>0.05）。FASN阳性表达与糖尿病及体质量指数相关。生存分析显示，三阴性乳腺癌患者c-Met及FASN阳性表达患者的5年无瘤生存期短于阴性表达患者（P < 0.05）。
结论 c-Met及FASN阳性表达参与了三阴性乳腺癌的侵袭、发展、复发及转移过程，可作为判断三阴性乳腺癌预后不良的生物学指标。

Abstract:
Objective To observe the expression of mesenchymal-epithelial transition factor (c-Met) and fatty acid synthase(FASN) in patients with triple-negative breast cancer, and their impacts on prognosis.
Methods Immunohistochemical staining (SP) method was used to detect the expression levels of c-Met and FASN protein in 218 cases of triple-negative breast cancer tissues and adjacent tissues, and the relationships between positive expression of c-Met, FASN and clinicopathological characteristics as well as their impacts on prognosis.
Results Among 218 patients, 130 cases (59.6%) had positive c-Met expression, and 142 cases (65.1%) had FASN positive expression, which were significantly higher than those of the adjacent tissues, and the positive expression levels of c-Met and FASN were correlated with axillary lymph node metastasis, TNM staging and histological grading (P < 0.05). However, they were not correlated with tumor diameter (P>0.05). Positive expression of FASN was also related to diabetes and body mass index. Survival analysis showed that the five-year tumor-free survival of triple negative breast cancer patients with positive expression of c-Met and FASN protein was significantly shorter than those of negative expression ones (P < 0.05).
Conclusion The positive expression of c-Met and FASN is involved in the invasion, development, recurrence and metastasis of triple-negative breast cancer, and can be used as one of the biological indicators to judge the poor prognosis of triple-negative breast cancer.

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