Objective  To observe clinical effect of oxytocin combined with cervical injection of carprost and ambutetriolin in preventing postpartum hemorrhage.

  Methods  A total of 70 women with natural childbirth were divided into observation group (n=37) and control group (n=33) according to random number table method. The control group received conventional intravenous infusion of 20 U oxytocin after delivery. On this basis, the observation group were injected carprost and ambutetriolin into the cervix. The total bleeding volume and the incidence of postpartum hemorrhage were compared between the two groups at different postpartum time points. Changes in hemodynamic indexes, hemoglobin (Hb) and red blood cell (RBC) levels before and after medication were compared, and adverse reactions after medication were recorded.

  Results  At 2 and 24 h after delivery, the total bleeding volume of the observation group was significantly less than that of the control group, and the incidence of postpartum hemorrhage was significantly lower than that in the control group (P < 0.05). After medication, the observation group had lower heart rate (HR), higher systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) than the control group (P < 0.05). Besides, the decreased value of Hb and RBC were lower than those in the control group (P < 0.05). There was no statistically significant difference in the incidence of total adverse reactions between the two groups (P>0.05).

  Conclusion  Postpartum intravenous infusion of oxytocin combined with cervical injection of carprost and ambutetriolin is effective in preventing postpartum hemorrhage, which can significantly deerease the bleeding volume, reduce the incidence of postpartum hemorrhage, and improve the hemodynamic indicators without increasing adverse reactions, and the combined therapy has higher safety.