Objective  To explore the effects of high flux hemodialysis (HFHD) and low flux hemodialysis (LFHD) on metabolism and renal function in patients with diabetic nephropathy(ND).

  Methods  A total of 60 DN patients were selected and divided into HFHD group and LFHD group according to random number table method, with 30 cases in each group, and the levels of renal function indexes and metabolic indexes were compared between the two groups.

  Results  Before dialysis, there were no significant differences in blood urea nitrogen (BUN), serum creatinine (SCr), β₂-microglobulin (β₂-MG) between the two groups (P>0.05); after dialysis, the above indexes were significantly higher in the HFHD group than those in the LFHD group(P < 0.05). There were statistically significant differences in hemoglobin (Hb), serum albumin (Alb), total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive protein (hs-CRP) and blood uric acid (BUA), blood calcium (Ca), phosphorus (P) and parathyroid hormone (PTH), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) between the two groups before and after dialysis (P < 0.05). The levels of TC, hs-CRP, P, PTH, IL-6 and TNF-α in the HFHD group after dialysis were significantly lower than those in the LFHD group (P < 0.05), but there were no statistically significant differences in other indexes (P>0.05).

  Conclusion  Compared with LFHD, HFHD in treatment of DN can effectively remove toxin, regulate body metabolism, and significantly improve the patient's renal function and inflammation.