Objective  To investigate and analyze the fear of disease progression and the existing psychological problems in human papillomavirus(HPV) positive women.

  Methods  The first stage of study was a qualitative study, 11 HPV-positive women were selected for semi-structured interviews. Based on the principle of data saturation, thematic analysis was used to collect the data. The second stage was quantitative research. Based on the results of the first qualitative stage, the HPV Positive Women's Fear of Disease Progression Scale was compiled. After the scale was formed, 180 cases of HPV positive women were selected as study subjects, and were investigated by general information questionnaire and HPV Positive Women's Fear of Disease Progression Scale.

  Results  The interview results showed that there were three aspects they concerneddisease progression as well as emotion response caused by infection, physical health, and family as well as social function. The total average score of the questionnaire was (55.58±9.23), emotional response score was (4.32±0.89), physical health score was (3.29±1.07), and family social function score was (2.95±1.11).

  Conclusion  HPV positive women have a serious psychological fear for disease progression, and they have a fear of physical health and family as well as social function. Medical staff should pay attention to the status of these patients with fear of disease progression to alliviate their fear of disease progression.