Abstract: With the aggravation of population aging, the prevalence of osteoporosis in the elderly is increasing year by year. Osteoporosis has become one of the most important public health problems in the world. In recent years, the clinical researches on osteoporosis mainly focus on osteoblasts and osteoclasts, but the mechanism is rarely studied. Circular RNA is a new stable non-coding RNA, which has been confirmed in lots of studies to play an important role in osteoporosis. In this paper, we searched the databases such as CNKI, Wanfang, PubMed and EMBASE with the key words of "osteoporosis" and "circular RNA", and summarized the research progress on role and mechanism of circular RNA on osteoporosis at home and abroad.