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右归丸联合二陈汤加减治疗多囊卵巢综合征的效果观察

Impact of Yougui Pill combined with modified Erchen Decoction in treating polycystic ovary syndrome

    摘要
  • 摘要:
      目的  观察右归丸联合二陈汤加减对多囊卵巢综合征（PCOS）的疗效及其对血清血管生成素样蛋白（Angptl）-2、Angptl-4和可溶性血管内皮生长因子受体-1（sFlt-1）的影响。
      方法  采用随机数字表法将92例PCOS患者分为观察组和对照组，每组46例。对照组采用常规西药治疗，观察组在对照组基础上采用右归丸联合二陈汤加减治疗。比较2组疗效和不良反应，并比较2组治疗前后痤疮评分、宫颈黏液评分、卵巢体积、卵泡数量、阻力指数（RI）、搏动指数（PI）、平均血流速度（Vm）和血清雌二醇、黄体生成素、促卵泡素、泌乳素、Angptl-2、Angptl-4、sFlt-1水平差异。
      结果  观察组总有效率为95.65%，高于对照组的78.26%，差异有统计学意义（P < 0.05）。观察组不良反应发生率为4.35%，低于对照组的19.57%，差异有统计学意义（P < 0.05）。治疗后，2组痤疮评分、RI、PI、Vm和雌二醇、黄体生成素、促卵泡素、泌乳素、Angptl-2、sFlt-1水平低于治疗前，且观察组低于对照组，差异有统计学意义（P < 0.01）；治疗后，2组卵巢体积小于治疗前，卵泡数量少于治疗前，且观察组卵巢体积小于对照组，卵泡数量少于对照组，差异有统计学意义（P < 0.01）；治疗后，2组宫颈黏液评分和Angptl-4水平高于治疗前，且观察组高于对照组，差异有统计学意义（P < 0.01）。
      结论  右归丸联合二陈汤加减治疗PCOS疗效显著，可明显改善患者症状，降低性激素水平，改善子宫血液循环，其机理可能与调节血清Angptl-2、Angptl-4和sFlt-1水平有关。

     

    Abstract:
      Objective  To observe the efficacy of Yougui Pill combined with modified Erchen Decoction in treating patients with polycystic ovary syndrome (PCOS), and its impact on serum angiopoietin-like protein (Angptl)-2, Angptl-4 and soluble fms-like tyrosine kinase receptor (sFlt)-1.
      Methods  A total of 92 PCOS patients were divided into observation group and control group according to the random numerical method, with 46 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Yougui Pill combined with modified Erchen Decoction on the basis of the control group. The efficacy and incidence of adverse reactions were compared between the two groups and the acne score, cervical mucus score, ovarian volume, follicle number, estradiol, luteinizing hormone, follicle stimulating hormone, prolactin, resistance index (RI), pulsatility index (PI), mean blood flow velocity (Vm), Angptl-2, Angptl-4 and sFlt-1 levels were compared in two groups before and after treatment.
      Results  The total effective rate in observation group was 95.65%, which was significantly higher than 78.26% in control group (P < 0.05). The incidence of adverse reactions in the observation group was 4.35%, which was significantly lower than 19.57% in the control group (P < 0.05). After treatment, the acne score, RI, PI, Vm, estradiol, luteinizing hormone, follicle stimulating hormone, prolactin, Angptl-2 and sFlt-1 levels of two groups were lower than treatment before, and were lower in the observation group than those in the control group(P < 0.01). After treatment, the ovarian volume in the two groups was smaller, and the number of follicles was less than that before treatment(P < 0.01). The ovarian volume was smaller and the number of follicles in the observation group was less than those in the control(P < 0.01). After treatment, the cervical mucus score and the level of Angptl-4 in the two groups were higher than before treatment, and the observation group was significantly higher than the control group (P < 0.01).
      Conclusion  Yougui Pill combined with modified Erchen Decoction in the treatment of polycystic ovary syndrome is obvious, which can significantly improve symptoms, reduce hormone levels and improve uterine blood circulation. The action mechanism may be related to the reduction of serum Angptl-2, Angptl-4 and sFlt-1 levels.

     

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