Abstract: Objective To analyze the effect of inhaling sevoflurane at concentration of ranging from 1.0% to 2.5% and maintaining Bispectral Index(BIS)of 45 to 55 on perioperative myocardial protection in coronary heart disease patients with non-cardiac surgery. Methods A total of 100 coronary heart disease patients undergoing thoracoabdominal surgery were selected and divided into groups A, B, and C according to random throwing method. The three groups had the same induction protocol, and group A was not given sevoflurane inhalation, with BIS of 35 to 44, group B was given sevoflurane inhalation at concentration of 2.6% to 4.0%, with BIS of 35 to 44, group C was given sevoflurane inhalation at concentration of 1.0% to 2.5%, BIS maintained 45 to 55. Results There were no significant differences in the operation time, intraoperative blood loss, and intraoperative fluid replacement volume among the three groups(P>0.05); the incidence rates of hypotension, bradycardia, and myocardial ischemia in the group C were significantly lower than those in the group B(P<0.05); there were no significant differences in cardiac troponin T(cTnT), hypersensitive C-reactive protein(hs-CRP)levels before intubation and at intubation in the three groups(P>0.05); cTnT and hs-CRP levels in the group C were significantly lower than groups A and B at extubation(P<0.05). Conclusion Sevoflurane inhalation at concentration of 1.0% to 2.5%and maintaining BIS of 45 to 55 can improve the efficacy in protection of perioperative myocardium in non-cardiac surgery patients with coronary heart disease, and can reduce the incidence of cardiovascular adverse events.