Abstract: Objective To investigate the clinical effect and safety of transurethral en-bloc resection of bladder tumors(TUERBT)with plasma column electrode in the treatment of primary non-muscle-invasive bladder cancer(NMIBC). Methods The clinical data of 36 confirmed patients with NMIBC by postoperative pathological examination was retrospectively analyzed. The patients were supplemented with immediate perfusion of pirobilin in the bladder after the operation, followed by maintenance perfusion chemotherapy. The efficacy of TUERBT was observed. Results All 36 patients successfully completed the surgeries. The tumor diameter ranged from 0.5 to 3.5 cm, with mean diameter of(2.3±0.7)cm, the operative time ranged from 10 to 45 min, with mean time of(24.5±8.5)min. Few blood loss during the operation occurred in the surgeries, no complications such as bladder perforation or reflection of obrurator nerve were observed. Postoperative bladder irrigation time was 0.5 to 2.0 d, with mean time of(1.0±0.5)d, the urethral catheterization time was 1~3 d, with mean time of(2.3±0.5)d. Postoperative hospital stay was 2 to 4 d, with mean time of(3.2±0.8)d. There were 6 cases in Ta stage and 30 cases in T₁ stage. During follow-up, 5 cases(13.9%)relapsed. Conclusion TUERBT with plasma column electrode is safe and effective in treating NMIBC, has the advantages of clear anatomic stratification, accurate postoperative pathological staging, fewer complication, and lower recurrence rate, so it is a safe and feasible surgical procedure.