Abstract: Objective To analyze the effect of Zishen Tonglin Paishi Decoction after soft ureteroscope lithotripsy and its impact on pain. Methods A total of 104 patients with urinary calculi admitted to our hospital were divided into control group and study group according to the random throwing method. Patients of both groups were treated with soft ureteroscopic lithotripsy. The control group was given conventional western medicine to assist with stone removal after the operation, while the study group was treated with Zishen Tonglin Paishi Decoction. The effective rate, the number of lithotripsy, stone removal time, Visual Analogue Scale(VAS)score before and after treatment, and the incidence of postoperative complications were compared. Results The total effective rate of the study group was 94.23%, which was significantly higher than 80.77% of the control group(P<0.05). The number of lithotripsy in the study group was significantly less, and the stone removal time was significantly shorter than that of the control group(P<0.05). At 3 days, 1 week and 2 weeks after treatment, the VAS scores of the study group were significantly lower than those of the control group(P<0.05); the postoperative complication rate in the study group was significantly lower than that in the control group(P<0.05). Conclusion The application of Zishen Tonglin Paishi Decoction after soft ureteroscopic lithotripsy can improve the effect of removing stones, relieve the pain of patients, and reduce the rate of postoperative complications.