Abstract: Urolithiasis is one of the most common diseases in Department of Urology, and it has the characteristics of complex etiology, complex stone composition and high recurrence rate. Potassium sodium hydrogen citrate granule is one of the frequently used drugs for stone prevention and treatment by urologists in China, and are commonly used in the treatment of uric acid calculi and prophylactic treatment of non-infectious stones. This study reviewed the basic and clinical researches of potassium sodium hydrogen citrate in recent years in order to provide references for clinical decision-making.