葛根汤加味治疗对椎动脉型颈椎病患者眩晕症状及血液流变学的影响

Effects of supplemented Gegen Decoction on vertigo symptoms and hemorheology in patients with cervical spondylotic vertebral arteriopathy

  • 摘要: 目的 探讨葛根汤加味治疗对椎动脉型颈椎病(CSA)患者眩晕症状和血液流变学的影响。 方法 选取76例CSA患者作为研究对象,应用抽签法分为对照组和联合组,每组38例。对照组采用盐酸氟桂利嗪胶囊治疗,联合组在对照组基础上加用中药汤剂葛根汤加味治疗,比较2组临床症状改善情况、血液流变学指标及椎基底动脉参数。 结果 联合组治疗总有效率为92.11%,高于对照组的73.68%,差异有统计学意义(P<0.05)。2组治疗后全血黏度、血浆黏度、纤维蛋白原水平和阻力指数、椎基底动脉内径、收缩期血流速度、舒张期血流速度均较治疗前改善,差异有统计学意义(P<0.05); 治疗后,联合组全血黏度、血浆黏度、纤维蛋白原水平和阻力指数低于对照组,椎基底动脉内径大于对照组,收缩期和舒张期血流速度高于对照组,差异均有统计学意义(P<0.05)。 结论 CSA患者采用葛根汤加味治疗,可扩大椎基底动脉血管内径,降低血液黏度及循环阻力,加快血流速度,缓解眩晕症状。

     

    Abstract: Objective To investigate the effects of supplemented Gegen Decoction on vertigo symptoms and hemorheology in patients with cervical spondylotic vertebral arteriopathy(CSA). Methods A total of 76 patients with CSA were selected and divided into control group and combined group according to the lottery method, with 38 patients in each group. The control group was treated with flunarizine hydrochloride capsule, and the combined group was treated with supplemented Gegen Decoctionon the basis of the control group. The improvement of clinical symptom, hemorheology indexes and vertebral basilar artery parameters were compared between the two groups. Results The effective rate of the combination group was 92.11%, which was significantly higher than 73.68% of the control group(P<0.05). After treatment, there were significant differences in whole blood viscosity, plasma viscosity, fibrinogen level, resistance index, vertebral basilar artery diameter, systolic blood flow velocity, and diastolic blood flow velocity between the two groups compared with those before treatment(P<0.05), the total blood viscosity, plasma viscosity, fibrinogen level and resistance index of the combined group were significantly lower than those of the control group, the vertebral basilar artery diameter was significantly greater than that of the control group, and the systolic and diastolic blood flow velocity were higher than those of the control group(P<0.05). Conclusion Supplemented - Gegen Decoction for patients with CSA can enlarge the inner diameter of vertebral basilar artery vessels, reduce blood viscosity and circulation resistance, accelerate speed of blood flow, and relieve symptom of vertigo.

     

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