Abstract: Objective To investigate application value of laparoscopic operation in treating gastric cancer patients with pyloric obstruction. Methods The data of 76 gastric cancer patients with pyloric obstruction was retrospectively analyzed, including 27 cases receiving conversion to open radical gastrectomy or palliative gastrectomy during laparoscopic approach, 39 patients only receiving gastrointestinal bypass surgery, and 10 cases receiving laparoscopic assisted radical gastrectomy. A total of 39 patients only receiving gastrointestinal bypass surgery were divided into total laparoscopic group(n=21)and laparotomy conversion group(n=18)according to different surgical approaches. Operative time, intraoperative blood loss, length of incision, recovery time of gastrointestinal function, time to first postoperative ambulation and food intake time, length of hospital stay, Visual Analogue Scale(VAS)score at 6 h after surgery and incidence of complications were recorded in the two groups. Results The perioperative indexes of the total laparoscopic group were significantly better than those of laparotomy conversion group, and the incidence of pulmonary infection was significantly lower than that of the laparotomy conversion group(P<0.01). Conclusion Laparoscopic operation has obvious advantages for progression phase gastric cancer patients with pyloric obstruction.