Abstract: Objective To observe the effect of tansoroxine combined with hydrochlorothiazide on urinary calculus removing after extracorporeal shock wave lithotripsy in patients with unilateral ureteral calculi. Methods A total of 76 ureteral calculi cases were selected as study objects, and were divided into control group and combination group according to random number table method, with 38 cases in each group. The two groups were treated with extracorporeal shock wave lithotripsy, the control group was treated with Niaoshitong Pill after operation, and the combined group was treated with tamsulosin combined with hydrochlorothiazide on the basis of the control group. The time of stone excretion and net excretion were observed in the two groups, and the stone removing rate, steinstrasse formation rate and adverse reaction rate were calculated. Results Stone removing rate and adverse reaction rate were 78.95% and 10.53%, respectively in the combined group, and 52.63% and 28.95%, respectively in the control group, significant differences were found in two groups(P<0.05). The first stone removing time of the combined group was(4.76±1.01)d and the net stone excretion time was(6.45±1.64)d, which were both significantly shorter than(5.88±1.23)d and(9.45±2.12)d in the control group(P<0.05). The steinstrasse formation rate in the combined group was 2.63%, and was 10.53% in the control group, there was no significant difference(P>0.05). Conclusion Tansoroxine combined with hydrochlorothiazide after extracorporeal shock wave - lithotripsy can improve the stone excretion rate, shorten the stone excretion time and reduce the risk of adverse reactions, so it has better efficacy.