Abstract: Objective To explore the effect of tiotropium bromide powder for inhalation combined with N-acetylcysteine(NAC)effervescent tablets on the clinical efficacy and lung function of patients with chronic obstructive pulmonary disease. Methods A total of 86 chronic obstructive pulmonary disease patients in our hospital were divided into control group and observation group, with 43 cases in each group, patients of two groups were given water electrolyte disorder correcting, resolving phlegm and relieving cough oxygen and other conventional treatments, the control group was given tiotropium bromide powder for inhalation on the basis of conventional treatment, the observation group was given tiotropium bromide powder for inhalation and NAC effervescent tablets based on the conventional treatment. Treatment was lasted for 4 weeks. Clinical efficacy, lung function, arterial blood gas related indexes and inflammatory factors were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that in the control group(P<0.05). After treatment, forced expiratory volume in one second(FEV₁), ratio of FEV₁ to forced vital capacity(FVC)(FEV₁/FVC), peak expiratory flow(PEF)and forced vital capacity(VC)were all increased in the two groups, and the above indexes in the observation group were significantly higher than those in the control group(P<0.05). After treatment, arterial partial pressure of oxygen［p_a(O₂)］ and oxygen saturation(SaO₂)in the two groups were increased, while partial pressure of carbon dioxide in - artery［p_a(CO₂)］ was decreased, and the observation group had higher levels of p_a(O₂)and SaO₂, and lower p_a(CO₂)level than the control group(P<0.05). Tumor necrosis factor-α(TNF-α), high sensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels were all decreased after treatment in both groups, and the above indexes in the observation group were all significantly lower than those in the control group(P<0.05). Conclusion Tiotropium bromide powder for inhalation combined with NAC effervescent tablets has a good clinical effect in the treatment of chronic obstructive pulmonary disease, which can improve patients' lung function and relieve inflammatory response.