肿瘤体积对局部晚期鼻咽癌预后影响的倾向匹配研究

胡勇, 张晶晶, 岳成山, 刘亚军, 王会霞, 高山, 张强, 张蕾, 袁亮

胡勇, 张晶晶, 岳成山, 刘亚军, 王会霞, 高山, 张强, 张蕾, 袁亮. 肿瘤体积对局部晚期鼻咽癌预后影响的倾向匹配研究[J]. 实用临床医药杂志, 2020, 24(20): 51-54. DOI: 10.7619/jcmp.202020014
引用本文: 胡勇, 张晶晶, 岳成山, 刘亚军, 王会霞, 高山, 张强, 张蕾, 袁亮. 肿瘤体积对局部晚期鼻咽癌预后影响的倾向匹配研究[J]. 实用临床医药杂志, 2020, 24(20): 51-54. DOI: 10.7619/jcmp.202020014
HU Yong, ZHANG Jingjing, YUE Chengshan, LIU Yajun, WANG Huixia, GAO Shan, ZHANG Qiang, ZHANG Lei, YUAN Liang. Effect of tumor volume on prognosis of patients with local advanced nasopharyngeal carcinoma: a propensity-matched study[J]. Journal of Clinical Medicine in Practice, 2020, 24(20): 51-54. DOI: 10.7619/jcmp.202020014
Citation: HU Yong, ZHANG Jingjing, YUE Chengshan, LIU Yajun, WANG Huixia, GAO Shan, ZHANG Qiang, ZHANG Lei, YUAN Liang. Effect of tumor volume on prognosis of patients with local advanced nasopharyngeal carcinoma: a propensity-matched study[J]. Journal of Clinical Medicine in Practice, 2020, 24(20): 51-54. DOI: 10.7619/jcmp.202020014

肿瘤体积对局部晚期鼻咽癌预后影响的倾向匹配研究

详细信息
    通讯作者:

    袁亮, E-mail: uniqueyuanliang@163.com

  • 中图分类号: R739.6

Effect of tumor volume on prognosis of patients with local advanced nasopharyngeal carcinoma: a propensity-matched study

  • 摘要: 目的 探讨肿瘤体积(GTV)对局部晚期鼻咽癌患者预后的影响。 方法 分析310例接受放化疗的Ⅲ~ⅣA/B期鼻咽癌患者的临床资料及随访资料,以受试者工作特征(ROC)曲线确定治疗前GTV最佳界值为34.1 mL, 选取GTV>34.1 mL患者106例纳入实验组,依据年龄、性别、卡氏功能状态量表(KPS)评分、T分期、N分期、临床分期采用倾向值匹配法,获得106例(1∶1匹配)GTV≤34.1 mL患者纳入对照组。采用Kaplan-Meier法计算生存率,以Cox回归模型进行预后因素分析。主要研究终点为无局部-区域进展生存率(LRRFS),次要研究终点为总生存率(OS)和无远处转移生存率(DMFS)。 结果 实验组4年LRRFS(80.2%)低于对照组(92.5%), 4年OS(77.4%)低于对照组(84.0%), 差异有统计学意义(P=0.008、0.043); 实验组与对照组4年DMFS分别为68.9%、74.5%, 差异无统计学意义(P=0.273); Cox回归模型显示, GTV>34.1 mL是LRRFS和OS的不良影响因素。 结论 GTV>34.1 mL是局部晚期鼻咽癌患者局部-区域进展和死亡的不良影响因素,对此类患者需增大治疗强度,以获得更好的临床疗效。
    Abstract: Objective To evaluate the primary gross tumor volume(GTV)on prognosis in patients with local advanced nasopharyngeal carcinoma. Methods The clinical data and follow-up data of 310 patients with nasopharyngeal carcinoma in Ⅲ to IVA/B phase undergoing chemoradiotherapy were retrospectively analyzed. The optimized critical value of GTV was confirmed as 34.1 mL by Receiver Operating Characteristic(ROC)curve analysis. A total of 106 cases with GTV>34.1 mL were included in the experimental group. Propensity matched study method was used to adjust for age, gender, Karnofsky Performance Status(KPS), tumor stage, node stage, and clinical stage. At last, a well-balanced cohort(106 cases who had GTV of less or equaling to 34.1 mL)was created by 1∶1 matching in the control group. Survival rate was calculated using Kaplan-Meier method, and prognostic factors were analyzed using Cox regression model. The primary end-point was loco-regional relapse-free survival rate(LRRFS), secondary end-points were overall survival(OS)and distant metastasis-free survival(DMFS). Results The experimental group had lower 4-year LRRFS and OS when compared to the control group(80.2% versus 92.5%, 77.4% versus 84.0%, P=0.008, 0.043). The 4-year DMFS of the experimental group and the control group were 68.9% and 74.5%, respectively, but no significant difference was found(P=0.273). Cox regression model showed that GTV >34.1 mL was an adverse influencing factor of LRRFS and OS. Conclusion GTV>34.1 mL is an adverse influencing - factor for loco-regional progress and death in local advanced nasopharyngeal carcinoma. It is necessary to increase the treatment intensity in order to obtain better clinical efficacy.
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    2. 彭爱琴,费正东,张阿娥,汤德. MR CE-T1WI的影像组学对鼻咽癌复发的预测. 宁夏医科大学学报. 2023(10): 1015-1020 . 百度学术

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出版历程
  • 收稿日期:  2020-08-17
  • 网络出版日期:  2020-12-21
  • 发布日期:  2020-11-12

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