Abstract: Objective To observe the effect of minimally invasive percutaneous plate osteotomy combined with locking compression plate in patients with limb fractures. Methods The clinical data of 80 patients with limb fractures was retrospectively analyzed, and they were divided into traditional group(n=39)and minimally invasive surgery group(n=41)according to different surgeries.The former group was given open reduction and plate fixation, while the latter group was given minimally invasive percutaneous plate osteotomy combined with locking compression plate.Operative indicators and fracture healing time were observed, joint function was assessed using the Johner Wruh score and the incidence of complications was calculated. Results The operation time and fracture healing time of the minimally invasive group were significantly shorter than those of the traditional group, and the intraoperative blood loss was significantly less than that of the traditional group(P<0.05).There was no significant difference in preoperative joint function score between the two groups(P>0.05). The joint function scores of two groups increased gradually at 1 month, 2 months and 3 months after surgery, and were higher at the above time points in the minimally invasive group than those in the traditional group(P<0.05).The complication rate of the minimally invasive group was 4.88%, which was significantly lower when compared with 23.08%of the traditional group(P<0.05). Conclusion Minimally invasive percutaneous plate osteotomy combined with locking compression plate has a good effect in patients with limb fractures, which can shorten operative time and fracture healing time, reduce intraoperative blood loss and enhance score of joint function.