Abstract: Objective To compare the clinical effect of percutaneous transforaminal endoscopic surgical system(TESSYS)technique and transforaminal lumbar interbody fusion in the treatment of lumbar disc herniation combined with nerve root canal stenosis. Methods A total of 110 patients with lumbar disc herniation complicated with nerve root canal stenosis were divided into TESSYS group and lumbar interbody fusion group, with 55 patients in each group. The treatment effect, and pain severity, lumbar function, conduction velocity of motor nerve as well as sensory nerve before and after operation of two groups were compared. At the same time, the operative related indexes and rate of complications of two groups were compared. Results Intraoperative blood loss, operative time and postoperative hospital stay were significantly better, and the excellent and good rate of TESSYS group after operation was significantly higher than that of lumbar interbody fusion group(P<0.05). After treatment, the Visual Analogue Scale(VAS)score and Oswestry Disability Index(ODI)score of the TESSYS group were significantly lower, the Japanese Orthopaedic Association(JOA)score was significantly higher, and the conduction velocity of sensory and motor nerves was significantly faster than those of the lumbar interbody fusion group(P<0.05). There was no statistically significant difference in the incidence of complications between the two groups(P>0.05). Conclusion Percutaneous TESSYS technique has a distinct curative effect, which can significantly relieve postoperative - pain, and improve lumbar function and nerve function of lower limbs.