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基于倾向性评分的老年高胆固醇血症影响因素分析

Analysis in influencing factors of hypercholesterolemia in the elderly based on propensity score

    摘要
  • 摘要:
      目的  基于倾向性评分对老年人发生高胆固醇血症的影响因素进行分析。
      方法  选取65岁以上的健康体检者763名作为研究对象，均接受体格检查和空腹血样检测，根据是否患高胆固醇血症将其分为高胆固醇血症组和非高胆固醇血症组，应用SPSS 23.0软件中的倾向性评分匹配模块分析老年人发生高胆固醇血症的相关因素。
      结果  本组老年人的高胆固醇血症的患病率为31.85%（243/763）。高胆固醇血症组的三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（Apo A1）、载脂蛋白B（Apo B）水平高于非高胆固醇血症组，总胆红素（TBIL）、直接胆红素（DBIL）水平低于非高胆固醇血症组，差异有统计学意义（P < 0.01）。Logistic多元回归分析提示，TG升高、HDL-C升高、Apo A1升高、TBIL降低、DBIL降低为高胆固醇血症的独立危险因素（P < 0.01）。倾向性评分匹配结果显示，TG升高、HDL-C升高、LDL-C升高、Apo A1升高、Apo B升高、TBIL降低、DBIL降低均是高胆固醇血症的危险因素（P < 0.05或P < 0.01）。
      结论  老年人高胆固醇血症的患病率较高，TG升高、HDL-C升高、LDL-C升高、Apo A1升高、Apo B升高、TBIL降低、DBIL降低均是引发高胆固醇血症的危险因素。

     

    Abstract:
      objective  To analyze influencing factors of hypercholesterolemia in the elderly based on propensity score.
      Methods  A total of 763 elderly people aged over 65 years who underwent physical examinations were selected as research objects. All the objects underwent physical examinations and their fasting blood samples were collected. According to the cholesterol levels, they were divided into hypercholesterolemia and non-hypercholesterolemia group, propensity score matching module of SPSS 23.0 software analysis was used to analyze the related factors of hypercholesterolemia.
      Results  The levels of triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) in the hypercholesterolemia group were significantly higher than those in non-hypercholesterolemia group(P < 0.01). Logistic multiple regression analysis suggested that the increase of TG, HDL-C, Apo A1 and the decrease of TBIL, DBIL were independently associated with hypercholesterolemia(P < 0.01). The results of propensity score matching showed that elevated levels of TG, HDL-C, LDL-C, Apo A1 as well as Apo B, and decreased levels of TBIL and DBIL were risk factors for hypercholesterolemia(P < 0.05 or P < 0.01).
      Conclusion  The prevalence of hypercholesterolemia in the elderly is higher, and elevated levels of TG, HDL-C, LDL-C, Apo A1 as well as Apo B, and decreased levels of TBIL and DBIL are risk factors for hypercholesterolemia.

     

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