Abstract: Objective To observe the effect of compound lidocaine mucilago in thoracoscopic lobectomy under general anesthesia with double-lumen tube. Methods A total of 80 patients with thoracoscopic lobectomy with double-lumen tube under general anesthesia were randomly divided into control group and study group, with 40 cases in each group. The control group was given white vasiline uniformly smeared on the double-lumen endotracheal intubation capsule and the front end, while the study group was given compound lidocaine mucilago coated on the double-lumen endotracheal intubation capsule and the front end. The dosage of intraoperative general anesthesia drug, cough during extubation, blood pressure at different time points, changes in heart rate and incidence of postoperative adverse reactions were compared between the two groups. Results There were no statistically significant differences in intraoperative dosage of general anesthesia drug, heart rate at different time points, blood pressure at time points of T₀, T₁ and T₃, and postoperative adverse reaction rate between the two groups(P>0.05). The blood pressure at time point of lobectomy(T₂)and catheter removal(T₄)in the study group was significantly lower than that in the control group(P<0.05). The incidence of cough during extubation in the study group was 20.00%, which was significantly lower than 47.50% in the control group(P<0.05). Conclusion Compound lidocaine mucilago can reduce the stress response during peri-intubation and extubation in thoracoscopic lobectomy patients with double-lumen tube under general anesthesia.