呼出气温度在儿童哮喘急性发作时及发作后的监测意义

Significance of exhaled breath temperature monitoring during and after acute attack of asthma in children

  • 摘要: 目的 观察儿童哮喘急性发作期间和发作后呼出气温度(EBT)的变化。 方法 选取6~12岁哮喘急性发作的住院儿童30例,比较不同时点EBT、呼出气一氧化氮(FeNO)、肺功能参数变化,分析EBT与FeNO、肺功能的相关性。 结果 哮喘急性发作儿童EBT测量值在入院第1天、出院后1周、出院后1个月等3个时点比较,差异均有统计学意义(P<0.05)。EBT与第1秒用力呼气量与用力肺活量比值(FEV1/FVC)呈负相关(r=-0.363, P=0.031), 与用力肺活量占预计值的百分比(FVC%pred)、第1秒用力呼气容积占预计值的百分比(FEV1%pred)、用力呼气中期流量(FEF 25%~75%)无相关性。入院时、出院后1周、出院后1个月各时点EBT与FeNO无相关性。 结论 EBT在儿童哮喘急性发作期显著升高,并且与FEV1/FVC呈负相关,可反映气道炎症反应程度。

     

    Abstract: Objective To observe change of exhaled breath temperature(EBT)during and after acute attack of asthma in children. Methods Totally 30 hospitalized children aged 6 to 12 years due to acute attack of asthma were selected. Changes of EBT, fraction of exhaled nitric oxide(FeNO)and pulmonary function parameters at different time points were compared, and correlations between EBT and FeNO as well as pulmonary function were analyzed. Results There were significant differences in EBT values in children with acute attack of asthma at the time points of the first day after hospital admission, one week after discharge, and one month after discharge(P<0.05). EBT was negatively correlated with forced vital capacity forced expiratory volume to in the first second ratio(FEV1/FVC)(r=-0.363, P=0.031), but had no correlations with forced vital capacity as a percentage of predicted value(FVC% pred), forced expiratory volume in the first second as a percentage of predicted value(FEV1% pred)and forced mid-expiratory flow(FEF 25%~75%). There were no correlations between EBT and FeNO at the time points of hospital admission, one week and one month after discharge. Conclusion EBT increases significantly in children with acute asthma, and is negatively correlated with FEV1/FVC, which can reflect the degree of airway inflammation.

     

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