Abstract:
Objective To detect the RNA expression level of uc.189 in cervical squamous cell carcinoma, and to observe the number of exosomes of uc.189 as well as its clinicopathological significance.
Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of uc.189 RNA in 58 cases of cervical squamous cell carcinoma and adjacent normal tissues. The number of uc.189 exosomes in cervical squamous cell carcinoma was observed under electron microscope, and the correlation between the number of uc.189 exosomes and pathological parameters of cervical squamous cell carcinoma was analyzed.
Results The expression level of uc.189 in the cervical squamous cell carcinoma was significantly higher than that in the adjacent normal tissues (P < 0.05). The high number of uc.189 exosomes in tumor tissue was all closely related to the differentiation degree, lymph node metastasis and TNM stage of cervical squamous cell carcinoma (P < 0.05).
Conclusion The uc.189 may be a new oncogene of cervical cancer. The uc.189 promotes the occurrence, development and metastasis of cervical squamous cell carcinoma through exosome.
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