Abstract: Objective To investigate the role of relaxation therapy combined with pain nursing in elderly patients with osteoporosis. Methods Sixty elderly osteoporosis patients treated in our hospital were selected and divided into two groups according to digital parity method. The control group(n=30)was given conventional nursing and the observation group(n=30)used relaxation therapy combined with pain care on the basis of conventional nursing. The pain degree, psychological status and sleep quality of the two groups were compared. Results The Visual Analogue Scale(VAS)score was(1.51±0.45)after nursing in the observation group, which was significantly lower than(3.54±0.56)in the control group, and the Pittsburgn Sleep Quality Index(PSQI)score was(5.41±1.78)in the observation group, which was significantly lower than(7.98±2.01)of the control group(P<0.05). The Self-rating Anxiety Scale(SAS)score and Self-rating Depression Scale(SDS)score of the observation group after nursing were significantly lower than those of the control group(P<0.05). Conclusion Relaxation therapy combined with pain nursing can alleviate pain, improve negative psychological mood and sleep quality in elderly patients with osteoporosis.