Abstract: Objective To observe the efficacy of therapy with compound Sanhuang Decoction in treating type 2 diabetes patients with erysipelas of lower limbs. Methods Totally 58 patients with type 2 diabetes and erysipelas of lower limbs were randomly divided into treatment group and control group, with 29 cases in each group. The treatment group was treated with impregnation therapy of compound Sanhuang Decoction, and the control group was treated with external application of Jinhuang Powder. The clinical efficacy, time of local symptoms and signs improvement and comfort degree were compared between the two groups. Results The total effective rate of the both groups was 100.00%, and there was no significant difference(P>0.05). The cure rate of the treatment group was 89.66%, which was significantly higher than 65.52% of the control group(P<0.05). The time of skin lesion disappearance, the time of pain disappearance, time of skin temperature to normal level and cure time in the treatment group were significantly shorter than those in the control group(P<0.05). After treatment, the total score of General Comfort Questionnaire(GCQ)and the scores of physiology, psychology, social culture and environment in both groups increased significantly, and the scores of above items in the treatment group were significantly higher than those in the control group(P<0.05). Conclusion Impregnation therapy with compound Sanhuang Decoction is effective in treating type 2 diabetes patients with erysipelas of lower limbs, which can quickly and effectively - relieve local symptoms and signs, and improve the comfort of patients.